Curcumin
别名: (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3
分子量: 368.38
CAS号: 458-37-7
Biochem/physiol Actions
A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity.1 Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
相关类型 Antioxidant, Bioactive Small Molecules, Biochemicals Found in Plants - sorted by compound type, Biochemicals Found in Plants - sorted by plant name, CI-CY,
Cancer Research, Cell Biology, Core Bioreagents, Curcuma longa, EGFR Tyrosine Kinase Inhibitors, Nitric Oxide Metabolism, Nitric Oxide Synthase Regulators, Nitric Oxide and Cell Stress, Nutrition Research, Research Essentials, Stains and Dyes, Tumor Growth Regulation, Zingiber officinale
vapor density 13 (vs air)
assay ≥80% (Curcumin)
      ≥94% (curcuminoid content)
solubility   ethanol: soluble1 mg/mL
             DMSO: >11 mg/mL
             0.5 M NaOH: soluble (then immediately diluted in PBS)

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