精品|地西他滨|Decitabine|5-Aza-2′-deoxycytidine|
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
Sigma | 暂无 | 暂无 | 现货 |
5-Aza-2′-deoxycytidine
别名: 2′-Deoxy-5-azacytidine, 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, Decitabine
CAS号: 2353-33-5
分子量: 228.21
General description
Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling “opening” chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.
Biochem/physiol Actions
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
相关类型 AN-AZ, Antitumor Agents, Bioactive Small Molecules, Cancer Research, Cell Biology,
Cell Signaling and Neuroscience, Gene Regulation, Gene Regulation and Expression
more...
assay ≥97%
solubility acetic acid: water (1:1): soluble50 mg/mL
精品|地西他滨|Decitabine|5-Aza-2′-deoxycytidine|信息由上海叶舟生物科技有限公司为您提供,如您想了解更多关于精品|地西他滨|Decitabine|5-Aza-2′-deoxycytidine|报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途