Replaces Prod. #: ALX-270-355
Antidiabetic thiazolidinedione. Potent and selective PPARγ ligand. Binds to the PPARγ ligand-binding domain and recruits ligand-specific transcriptional coactivators at 1µM. In skeletal muscle and adipocyte cell cultures, the EC50 of troglitazone is about 10µM. Displaces [125I]SB-236636 with an IC50=7.9 µM. Stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. Induces apoptosis in human vascular smooth muscle cells and inhibits the growth of a variety of human cancer cells including lung, bladder and myeloid leukemia cells.
Product Specification
Formula: C24H27NO5S
MW: 441.5
Purity: ≥98% (TLC)
Appearance: White to yellow solid.
CAS: 97322-87-7
MI: 14: 9769
RTECS: XJ5813130
Source/Host: Synthetic.
Solubility: Soluble in DMSO (>25mg/ml), 100% ethanol (>25mg/ml, warm) or dimethyl formamide.
Shipping: AMBIENT
Long Term Storage: +20°C
Use/Stability: Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
Background / Technical Information: Troglitazone is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, troglitazone should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Troglitazone has a solubility of 100µg/ml in a 1:6 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.Note: Product is not sterile.

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