Replaces Prod. #: ALX-430-020
Selective inhibitor of cGMP-specific phosphodiesterase (PDE5: IC50=0.2-0.8µM, PDE1: IC50=2.6µM, PDE2: IC50>10µM, PDE3: IC50>10µM, PDE4: IC50>10µM). Increases cGMP levels in SHR plasma. Reverses nitroglycerin tolerance in vitro .
Product Specification
Alternative Name: M&B 22,948, 1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one, 2-(2-Propoxyphenyl)-8-azahypoxanthine
Formula: C13H13N5O2
MW: 271.3
Purity: ≥98% (TLC)
Appearance: White to tan powder.
CAS: 37762-06-4
Solubility: Soluble in 1M sodium hydroxide, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.11mg/ml), DMSO (25mg/ml) or 100% ethanol (5 mg/ml); insoluble in water.
Shipping: AMBIENT
Long Term Storage: +20°C
Use/Stability: Stable for up to 5 years after receipt when stored at +20°C. Stock solutions are stable for up to 6 months at -20°C.
Hazard: IRRITANT.

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