Product Specification
Alternative Name: 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl
Formula: C15H17N2O2SCl·HCl
MW: 361.3
Purity: 99%
Appearance: White solid.
CAS: 105637-50-1
Solubility: Soluble in DMSO (10mg/ml) and ethanol/water (1:1, 10mg/ml).
Shipping: AMBIENT
Long Term Storage: +4°C
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C.
Handling: Protect from light.
Replaces Prod. #: ALX-270-084
Selective inhibitor of MLC kinase (Ki=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC50=10-50 µM). Also known to inhibit PKA (IC50=20 µM) and S6 kinase (IC50=50 µM). Does not inhibit PI 3-kinase.

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