Product Specification
Alternative Name: UCN-1028C
Formula: C44H38O14
MW: 790.6
Purity: ≥99% (TLC)
Appearance: Dark red solid.
CAS: 121263-19-2
Solubility: Soluble in DMSO or dimethyl formamide; insoluble in water.
Shipping: AMBIENT
Long Term Storage: +4°C
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C.
Handling: Protect from light.
Replaces Prod. #: ALX-350-027
Potent and selective inhibitor of the protein kinase C (PKC). Inhibition is via interaction with the regulatory DAG binding site and phorbol ester binding site. Inhibition of PKC has been found to be light dependent. At higher concentrations inhibits myosin light chain kinase, cAMP-dependent protein kinase, protein kinase G, pp60v-src protein tyrosine kinase and DAG kinase. It also inhibits Phospholipase D1 and D2. Induces apoptotic DNA fragmentation and cell death. Kills breast cancer cells. Has antiviral potential.
Inhibits cardiac L-type Ca2+ channels. Cell permeable.

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