Embelin is a novel cell-permeable inhibitor of XIAP (X-linked inhibitor of apoptosis) which was discovered by screening a library of natural products derived from traditional Chinese medicine. It binds to the XIAP BIR3 domain preventing its binding to and inhibition of caspase-9 and effector caspases. Embelin selectively inhibits cell growth in cancer cells expressing high levels of XIAP (IC50 = 3-6 µM) versus normal cells with low levels of XIAP.
Product Specification
Formula: C17H26O4
MW: 294.4
Purity: ≥98%
Appearance: Orange solid
CAS: 550-24-3
Solubility: Soluble in DMSO (10mg/ml)
Shipping: AMBIENT
Long Term Storage: -20°C

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途