Replaces Prod. #: ALX-550-411
A potent inhibitor of anandamide uptake (IC50=7.3nM). Systemic administration to rodents elevates brain anandamide levels and shows efficacy in a rodent model of persistent pain. LY2183240 also inhibits FAAH hydrolytic activity (IC50=12.4nM) as well as other brain serine proteases and represents a new chemotype for the design of new selective FAAH inhibitors. Radiolabeled LY2183240 has been used to identify a high-affinity, saturable anandamide transporter binding site on RBL-2H3 cell membranes distinct from FAAH.
Product Specification
Formula: C17H17N5O
MW: 307.4
Purity: ≥98% (TLC)
Appearance: White solid.
CAS: 874902-19-9
Solubility: Soluble in DMSO (>25mg/ml), 100% ethanol (12mg/ml) or dimethyl formamide.
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
Use/Stability: Store as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

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