Replaces Prod. #: ALX-550-522
Leelamine binds weakly to the CB1 receptor (Ki= 5 µM) and does not stimulate G-protein activity. It exhibits potent behavioural activity reminiscent of THC which are reversed by the CB1 antagonist SR141716A. Paradoxically it is also active in CB1 knockout mice indicating that other receptors or targets mediate its effects. Also inhibits pyruvate dehydrogenase kinase (IC50=9.5µM).
Product Specification
Alternative Name: Dehydroabietylamine
Formula: C20H31N . HCl
MW: 321.9
Purity: ≥98% (TLC)
Appearance: White solid.
CAS: 1446-61-3
Source/Host: Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). Sparingly soluble in dimethyl formamide.
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
Use/Stability: Store as supplied, at -20°C, for up to 1 year. Store solutions at -20°C for up to 3 months.

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