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Marine sesterterpenoid. Irreversibly inhibits human synovial phospholipase A2 (PLA2, IC50=0.02-0.2µM depending on substrate) as well as bee (IC50=0.05µM) and cobra venom (IC50=2µM) PLA2 by covalently modifying lysine residues. Inhibits human recombinant sPLA2 (IC50=4.7µM) selectively over cPLA2. Also inhibits phospholipase C (PLC, IC50=1.5µM) and Ca2+ channels. Inhibits superoxide generation in polymorphonuclear leukocytes.
Inhibits the release of arachidonate in cultured mouse peritoneal macrophages and in a mouse in vivo model. Has anti-inflammatory and analgesic properties. Shows strong quorum sensing antagonism.
Product Specification
Formula: C25H36O5
MW: 416.6
Purity: ≥98% (TLC)
Appearance: Colorless to off-white solid or oil.
CAS: 75088-80-1
Solubility: Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) or methanol.
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.

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