Geldanamycin实验专用试剂,其它生化试剂

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Potent antitumor antibiotic. Inhibitor of pp60src tyrosine kinase and of c-myc gene expression in murine lymphoblastoma cells. Inhibits the transforming activity of abl, erbB, fps, src, and yes. Binds specifically to heat shock protein 90 (HSP90) and to its endoplasmic reticulum homolog GP96 (GRP94). Capable of destabilizing several oncogene and proto-oncogene products. Potent inhibitor of the nuclear hormone receptor family. Protects against α-synuclein toxicity to dopaminergic neurons in Drosophila.
Destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines. Inhibits basal and hypoxia-induced expression of c-Jun (IC50=75nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase (JNK) activity. Inhibits telomerase activity through inhibition of HSP90, a chaperone required for the assembly and activation of telomerase in human cells. Hsp90 inhibitors geldanamycin or 17-DMAG reduces the uptake of Chaperone Mediated Autophagy (CMA) substrates by isolated lysosomes.~10-fold more potent than herbimycin A (Prod. No. BML-EI227)
Product Specification
Formula: C29H40N2O9
MW: 560.6
Purity: ≥95% (HPLC)
Appearance: Yellow solid.
CAS: 30562-34-6
RTECS: LX8920000
Solubility: Soluble in DMSO (10mg/ml); insoluble in water.
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling: Protect from light.

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