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A potent and selective inhibitor of the Src family tyrosine kinases. Inhibits Lck (IC50=4 nM), Fyn (IC50=5 nM), and Hck (IC50=5 nM). It displays weaker inhibition of EGFR (IC50=480 nM) and no inhibition of ZAP-70 (IC50 100 µM) and JAK2 (IC5050 µM). PP2 is a useful tool for probing the involvement of Src family tyrosine kinases in cellular signaling.
Product Specification
Formula: C15H16CIN5
MW: 301.8
Purity: ≥ 98% (TLC)
Appearance: Off-white solid.
CAS: 172889-27-9
Solubility: Soluble in DMSO (25mg/ml).
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

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