17-AAG正品原装
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
Biomol | 暂无 | 暂无 | 现货 |
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17-AAG is a less toxic and more stable analog of geldanamycin. It is an HSP90 inhibitor that displays a 100-fold higher affinity for HSP90 derived from tumor cells compared to HSP90 from normal cells. 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol, cisplatin, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α. Inhibitor of telomerase activity. Inducer of apoptosis with antitumor activity.
Inducer of macroautophagy.
Product Specification
Alternative Name: 17-(Allylamino)-17-desmethoxygeldanamycin
Identity: Identity determined by 1H-NMR.
Formula: C31H43N3O8
MW: 585.7
Purity: ≥98% (TLC)
Appearance: Red to dark red powder.
CAS: 75747-14-7
Source/Host: Semisynthetic derivative from geldanamycin.
Solubility: Soluble in DMSO (>20mg/ml) or 100% ethanol (10mg/ml).
Shipping: AMBIENT
Long Term Storage: -20°C
Handling: Protect from light.
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途