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Selective, reversible and ATP-competitive inhibitor of IKK2 (IC50=11.2µM). Does not inhibit other IKK isoforms or other serine/threonine or tyrosine kinases. Inhibits transcription of NF-κB dependent genes in IL-1β-induced rheumatoid arthritis-derived synovial fibroblasts in a dose-dependent fashion.
Product Specification
Formula: C9H8N2OS2
MW: 224.3
Purity: ≥98% (TLC)
Appearance: Yellow solid
CAS: 354812-17-2
Solubility: Soluble in DMSO (>25mg/ml)
Shipping: AMBIENT
Long Term Storage: -20°C

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