N-Acetyl-S-farnesyl-L-cysteine,其它生化试剂

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Replaces Prod. #: ALX-290-001
Members of the Ras superfamily of G proteins, γ-subunits of heterotrimeric G proteins and the α-subunit of cGMP phosphodiesterase from retinal rods are all carboxyl methylated at carboxy-terminal S-farnesylcysteine residues. AFC specifically inhibits the S-farnesylcysteine methyl transferase (Km=20 µM) in cell free extracts and in whole cells. It inhibits carboxyl methylation of p21ras platelet Rap15 and the γ-subunit of transducin. It blocks receptor-mediated signal transduction in platelets and neutrophils not by inhibiting the methyltransferase, but possibly by inhibiting capacitative Ca2+ entry.
Product Specification
Formula: C20H33NO3S
MW: 367.5
Purity: ≥98% (TLC)
Appearance: Pale yellow oil.
CAS: 135304-07-3
Solubility: Soluble in DMSO (25mg/ml), methanol or 100% ethanol (25mg/ml).
Shipping: AMBIENT
Long Term Storage: -20°C
Handling: Keep under inert gas.

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