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Active carboxylate form of Lovastatin (Prod. No. BML-G226). Active in whole cells as well as cell-free assays. Inhibits cholesterol/ isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1 nM) and blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Causes cells to arrest early in the G1 phase.
Product Specification
Alternative Name: Mevinolin . sodium salt, 6-α-Methylcompactin . sodium salt
Formula: C24H36O6·Na
MW: 444.5
Purity: ≥97% (TLC)
Appearance: White solid.
CAS: 75225-50-2
MI: 14: 5586
Solubility: Soluble in DMSO (10mg/ml) or 100% ethanol (10mg/ml).
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.

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