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An intercalating transcription inhibitor and antineoplastic antibiotic. Inhibits transcription by binding to DNA at dG residues. Induces apoptosis in many cell lines, but suppresses in PC12 cells induced by topoisomrease II inhibitor etopside. Used at 5-10µg/ml in cell culture for haltiong transcription. The product is not sterile.
Product Specification
Formula: C62H86N12O16
MW: 1255.5
Purity: ≥98% (TLC)
Appearance: Red-orange solid.
CAS: 50-76-0
Source/Host: Isolated from Streptomyces parvulus
Solubility: Soluble in DMSO (>20mg/ml) ,100% ethanol (1mg/ml) or methanol
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Sensitive to strong acids and bases. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Hazard: VERY TOXIC.
Handling: Hygroscopic.
Protect from light.

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