订购电话:021-51870956
在线QQ:470003480
快来www.haoranbio.com体验在线订购给您带来的快捷和方便吧！
Trichostatin A (TSA) is a potent and reversible inhibitor of histone deacetylases. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin. In cells latently infected with HIV-1, TSA induced the transcriptional activation of the HIV-1 promoter, which resulted in a marked increase in virus production. In NIH 3T3 cells, TSA induced reversion of oncogenic ras-transformed cells to a normal morphology. In Jurkat cells, TSA inhibited IL-2 gene expression (IC50=73 nM) and displayed immunosuppressive activity in a mouse model.
Induces increased acetylation of GATA4, a cardiac-specific transcription factor and increases cardiac muscle cell differentiation. Trichostatin A is a useful tool for induction of hyperacetylation of cellular histones and for further elucidation of their role in gene expression. Induces cell growth arrest at both G1 and G2/M phases. may induce apoptosis in some cases.
Product Specification
Formula: C17H22N2O3
MW: 302.4
Purity: ≥99% (HPLC)
Appearance: solid
Formulation: lyophilized
CAS: 58880-19-6  
Source/Host: Isolated from Streptomyces hygroscopicus
Solubility: Soluble in DMSO, dimethyl formamide, acetonitrile, methanol or 100% ethanol
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Hazard: HARMFUL.
IRRITANT.

TrichostatinA信息由上海叶舟生物科技有限公司为您提供，如您想了解更多关于TrichostatinA报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途