产地：Biomol
货号：BML-GR357-0005
规格：5mg
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The MRN-ATM pathway is essential for sensing the signaling from DNA double-strand breaks. Mirin is an inhibitor of MRN discovered using a forward chemical genetic screen. It prevents MRN-dependent activation of ATM without affecting ATM protein kinase activity and it inhibits Mre11-associated exonuclease activity. IC50=66μM. It abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells.
Product Specification
Formula: C10H8N2O2S
MW: 220.3
Purity: 95% (TLC)
Appearance: Yellow solid.
CAS: 299953-00-7
Solubility: Soluble in DMSO (25mg/ml) or DMF (25mg/ml).
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C

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