货号：BML-N159-0001
产地：Biomol
A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM.
Product Specification
Formula: C38H45NO7
MW: 627.8
Purity: ≥98% (TLC)
Appearance: Yellow-orange solid.
Solubility: Soluble in DMSO (20mg/ml) or ethanol (20mg/ml).
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
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