IKK-NBDPeptide正品订购,其它生化试剂

产地：Biomol
货号：BML-P607-0500
BML-P607-0500 0.5 mg
The peptide consists of two domains – an antennapedia homeodomain that confers cell permeability and the T735 to E745 region of IKKβ which is the NEMO binding domain (NBD). It is a selective inhibitor of NFκB activation. Blocks interaction of NEMO (an IKB complex regulatory protein) with the IκB kinase complex. The peptide (100 µM) inhibits E-selectin expression in human umbilical vein endothelial cells treated with TNFα and inhibits LPS-induced nitric acid release from a macrophage cell line In an experimental mouse model of acute inflammation, IKK-NBD peptide (topically applied) inhibited PMA induced ear inflammation.
Sold under license from Vanderbilt University
Product Specification
MW: 3694.0
Purity: ≥95% (HPLC)
Appearance: Lyophilized solid
Sequence: Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu
Solubility: Soluble in DMSO (20mM). Note: This peptide will precipitate when added to tissue culture medium, even to 100µM. However, enough will remain in solution to enter many cell types.
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
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