BML-PI134-0001 1 mg  
Inhibitor of TNF-α processing (IC50 is approximately 100 nM using in vitro TNF peptide cleavage assay), similar to TAPI-0, but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF-α  (IC50=50-100 µM)1, APP (1-8 µM), ACE (10 µM), IL6R (5-10 µM), TNFRI (5-10 µM), TNFRII (25-50 µM)5, and ObRa (leptin receptor), but not CSF-14, from cells in culture.
Product Specification
Alternative Name: IC2, N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine 2-aminoethyl amide
Formula: C26H37N5O5
MW: 499.30
Purity: ≥98% (HPLC)
Appearance: Lyophilized solid.
Sequence: N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine 2-aminoethyl amide
Solubility: Soluble in DMSO or methanol
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
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