Acetyl CoA Carboxylase 1(ACC1)Phos(pS79)(ACACA)antibody
Cat.#: 2327-1
Rabbit Monoclonal Antibody
Clone ID: EP1885Y
Swiss Prot: Q13085
Mol Weight: 280kDa
Size: 100ul

Description
Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK at Ser79 and others) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).

Recommended Applications
WB, ICC

Applications and Recommended Dilution Factors
WB: 1:1000 - 10,000
ICC: 1:100 - 250

Species Reactivity
Human

Cross reactivity determined by western blot only.

Products Data

A. Western blot analysis on A431 cell lysates using anti-Phospho-ACC1 (pS79) RabMAb (cat. #2327-1), 1:10,000 dilution. Cells were either (A) untreated (B) treated with LP

Specificity
A phospho specific peptide corresponding to residues surrounding serine 79 of human ACC1 was used as an immunogen. This antibody detects ACC1 phosphorylated at serine 79.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
ACACA antibody, ACAC antibody, ACC antibody, ACC1 antibody, ACCA antibody, Biotin carboxylase antibody, ACC-alpha antibody

Description References
1. Jianqiang M, et al. PNAS 100:7515-7520, 2003
2. Girad J, et al. The FASEB Journal 8:36-42, 1994.
3. Wakil SJ, et al. Annu Rev Biochem 52:537-539
4. Abu-Elheiga L, et al. Science 291: 2613-2616. 2001.

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