ACVR1B antibody
Cat.#: 3521-1
Rabbit Monoclonal Antibody
Clone ID: EPR4816
Swiss Prot: P36896
Mol Weight: 52kDa
Size: 100ul

Description
ACVR1B is an activin A type IB receptor. Activins are dimeric growth and differentiation factors that belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases, which include at least two type I and two type II receptors. ACVR1B is a type I receptor that is essential for signaling. Mutations in this protein are associated with pituitary tumors.

Recommended Applications
WB, FC

Applications and Recommended Dilution Factors
WB: 1:10,000-50,000
FC: 1:10 - 100

Species Reactivity
Human, Mouse, Rat

Species cross-reactivity is based on WB analysis

Products Data 

 

Western blot analysis on (A) HepG2, (B) SH-SY5Y, (C) U87-MG, and (D) 293T cell lysates using anti-ACVR1B RabMAb (cat. #3521-1).
Flow cytometric analysis of permeabilized 293T cells using anti-ACVR1B RabMAb (red) (catalog # 3521-1) or a rabbit IgG (negative) (green).

Specificity
A synthetic peptide corresponding to residues in the intracellular domain of human ACVR1B was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
ACVR1B antibody, ACTRIB antibody, ACVRLK4 antibody, ALK4 antibody, SKR2 antibody, Activin receptor type-1B antibody, Serine/threonine-protein kinase receptor R2 antibody

Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途