Alpha B Crystallin(CRYAB)antibody
Cat.#: 2523-1
Rabbit Monoclonal Antibody
Clone ID: EPR2752
Swiss Prot: P02511
Mol Weight: 22kDa
Size: 100ul

Description
Alpha B Crystallin, first identified as a structural component of the vertebrate eye lens, is expressed at high levels in lens and at lower levels in a number of other tissues, most notably cardiac and skeletal muscle, kidney, and brain (1). It is a major protein component of Rosenthal fibers, which massively accumulate in the brains of patients suffering from Alexander's disease (2). The major phosphorylation site of Alpha B Crystallin in brains of patients with Alexander's disease or Alzheimer's disease as well as in aged controls is Serine 59 (3). Racemization, isomerization, and oxidation of Alpha B Crystallin are said to occur spontaneously in the aging process (4).

Recommended Applications
WB, IHC, ICC

Applications and Recommended Dilution Factors
WB: 1: 5,000 - 50,000
IHC: 1:100 - 250
ICC: 1:25 - 50

Species Reactivity
Human, Rat

Cross reactivity determined by western blot only.

Products Data 

 

A. Western blot analysis on (A) fetal heart and (B) rat eyeball lysates using anti-Alpha B Crystallin RabMAb (cat. # 2523-1), dilution (A) 1:5000 and (B) 1:20,000. 
B. Immunohistochemical analysis of paraffin-embedded human heart muscle using anti-Alpha B Crystallin RabMAb (cat. #2523-1).

Specificity
A synthetic peptide corresponding to residues on the C terminus of human Alpha B Crystallin was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
CRYAB antibody, CRYA2 antibody, CTPP2 antibody, HSPB5 antibody, Alpha-crystallin B chain antibody, Renal carcinoma antigen NY-REN-27 antibody, Rosenthal fiber component antibody

Description References
1. Dubin RA, et al. Genomics 7(4):594-601, 1990
2. Iwaki A, et al. Neurosci Lett 140(1):89-92, 1992
3. Kato K, et al. J Neurochem 76(3):730-6, 2001
4. Fujii N, et al. Biochim Biophys Acta 204(2):157-63, 1994 

AlphaBCrystallin(CRYAB)antibody信息由上海希美生物科技有限公司为您提供，如您想了解更多关于AlphaBCrystallin(CRYAB)antibody报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途