Alpha-2 Catenin(CTNNA2)antibody
Cat.#: 2046-1
Rabbit Monoclonal Antibody
Clone ID: EPR1795
Swiss Prot: P26232
Mol Weight: 102kDa
Size: 100ul

Description
It has been shown that alpha N-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. Results suggest that alpha N-catenin is a key regulator for the stability of synaptic contacts (1). We show here that antibodies against alpha catenin also immunoprecipitate complexes that contain human N-cadherin, mouse P-cadherin, chicken A-CAM (adherens junction-specific CAM; also called N-cadherin) or Xenopus U-cadherin, demonstrating that alpha catenin is complexed with other cadherins (2).

Recommended Applications
WB, ICC, IP

Applications and Recommended Dilution Factors
WB: 1:1000 - 2000
ICC: 1:50
IP: 1:50

Species Reactivity
Human, Mouse, Rat

Cross reactivity determined by western blot only.

Products Data

A. Western blot analysis on mouse brain lysate using anti-alpha 2 Catenin RabMAb (cat. # 2046-1), dilution 1:2000.

Specificity
A synthetic peptide corresponding to residues in human α-2 Catenin was used as an immungen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
CTNNA2 antibody, CAP-R antibody, CAPR antibody, CT114 antibody, CTNR antibody, DKFZp686H02198 antibody, Catenin alpha-2 antibody, Alpha N-catenin antibody, Alpha-catenin-related protein antibody

Description References
1. Abe K, et al. Nat Neurosic 7(4):357-63, 2004
2. Herrenknecht K, et al. Proc Natl Acad Sci 88(20): 9156-60, 1991 

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