APC antibody
Cat.#: 1701-1
Rabbit Monoclonal Antibody
Clone ID: EP701Y
Swiss Prot: P25054
Mol Weight: 312/160kDa
Size: 100ul

Description
Adenomatous polyposis coli (APC) is a protein that plays a critical role in several cellular processes. APC is a tumor suppressor, regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division and associates with other proteins involved in cell attachment and signaling (1). APC regulates β-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration (2-3). Mutations cause the production of an APC protein that is abnormally short and nonfunctional. Defects in APC are a cause of familial aenomatous polyposis (FAP), Turcot syndrome, medulloblastoma (MDB), and other cancers. (4-6)

Recommended Applications
WB, IHC, ICC, IP

Applications and Recommended Dilution Factors
WB: 1:500-1,000
IHC: 1:50-100
ICC: 1:50-100
IP: 1:50

Species Reactivity
Human, Rat

Cross reactivity determined by western blot only.

Products Data 

 

A. Western blot analysis on 293 cell lysate using anti-APC RabMAb (cat. # 1701-1), dilution 1:1,000.
B. Immunohistochemical analysis of paraffin-embedded human colon carcinoma using anti-APC RabMAb (cat. # 1701-1).

Specificity
A synthetic peptide corresponding to residues near the N-terminus of human APC was used as immunogen. This antibody is predicted to detect isoform 2 based on sequence analysis.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
APC antibody, BTPS2 antibody, DP2 antibody, DP2.5 antibody, DP3 antibody, GS antibody, Adenomatous polyposis coli protein antibody, Deleted in polyposis 2.5 antibody

Description References
1. Senda T, Shimomura A, Iizuka-Kogo A. Anat Sci Int. 2005 Sep;80(3):121-31.
2. Narayan S, Roy D. Mol Cancer. 2003 Dec 12;2:41.
3. van Es JH, Giles RH, Clevers HC. Exp Cell Res. 2001 Mar 10;264(1):126-34.
4. Jarvinen HJ, Peltomaki P. Eur J Gastroenterol Hepatol. 2004 Jan;16(1):5-8.
5. Jaiswal AS, Balusu R, Narayan S. Front Biosci. 2005 May 1;10:1118-34.
6. Cohen MM Jr. Am J Med Genet A. 2003 Nov 1;122(4):303-14. 

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