Axin-2(AXIN2)antibody
Cat.#: 3465-1
Rabbit Monoclonal Antibody
Clone ID: EPR2005(2)
Swiss Prot: Q9Y2T1
Mol Weight: 95kDa
Size: 100ul

Description
The Axin-related protein, Axin-2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. Axin-2 has been linked to a frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in Axin-2 have been associated with colorectal cancer with defective mismatch repair.

Recommended Applications
WB, IP

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IP: 1:10 - 100

Species Reactivity
Human, Mouse, Rat

Species cross-reactivity is based on WB analysis

Products Data

 
Western blot analysis on (A) MCF-7, (B) SW480, and (C) PC-3 cell lysates using anti-Axin-2 RabMAb (cat. #3465-1).

Specificity
A synthetic peptide corresponding to residues in human Axin-2 was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
AXIN2 antibody, AXIL antibody, DKFZp781B0869 antibody, MGC10366 antibody, MGC126582 antibody, Axin-2 antibody, Axis inhibition protein 2 antibody, Conductin antibody

Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8. 

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