ABCG2(BCRP)Antibody (Center)
Cat.#: T0329
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: Q9UNQ0
Mol Weight: 72kDa
Size: 100ug

Description
ABCG2 is a membrane-associated protein included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.

Recommended Applications
WB, ELISA

Applications and Recommended Dilution Factors
WB: 1:50~100
ELISA: 1:1,000

Species Reactivity
Human

Products Data

Western blot analysis of ABCG2 Antibody (Center) in 293 cell line lysates (35ug/lane). ABCG2(arrow) was detected using the purified Pab (1:60 dilution).

Specificity
This ABCG2 (BCRP) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313~342 amino acids from the center region of human ABCG2.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Alternative Names
ABCG2 antibody, ABC15 antibody, ABCP antibody, BCRP antibody, BCRP1 antibody, BMDP antibody, CD338 antibody, CDw338 antibody, EST157481 antibody, MGC102821 antibody, MRX antibody, MXR antibody, MXR1 antibody, ATP-binding cassette sub-family G member 2 antibody, Breast cancer resistance protein antibody, CDw338 antibody, Mitoxantrone resistance-associated protein antibody, Placenta-specific ATP-binding cassette transporter antibody

Description References
Xie,Y., J. Biol. Chem. 283 (6), 3349-3356 (2008)
Tamura,A., Drug Metab. Pharmacokinet. 22 (6), 428-440 (2007) 

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途