ACTR-I antibody
Cat.#: S2210
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: Q04771
Mol Weight: 57.16kDa
Size: 100ul

Description
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq]

Recommended Applications
WB, IHC

Applications and Recommended Dilution Factors
WB: 1:500-1:3000
IHC: 1:100-1:500

Species Reactivity
Human

Other species have not been tested

Products Data 

 

Sample (30ug of whole cell lysate)
A: Hep G2
7.5% SDS PAGE
diluted at 1:1000
Immunohistochemical analysis of paraffin-embedded CA922 xenograft, using ACTR-I antibody at 1:100 dilution.

Specificity
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 125 and 505 of ACTR-I

Storage Condition and Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.

Alternative Names
ACVR1 antibody, ACTRI antibody, ACVR1A antibody, ACVRLK2 antibody, ALK2 antibody, FOP antibody, SKR1 antibody, TSRI antibody, Activin receptor type-1 antibody, TGF-B superfamily receptor type I antibody 

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