ACVR2B Antibody(N-term)
Cat.#: T2022
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: Q13705
Mol Weight: 58kDa
Size: 100ug

Description
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor) displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

Recommended Applications
WB, IHC, ELISA

Applications and Recommended Dilution Factors
WB: 1:100~500
IHC: 1:50~100
ELISA: 1:1,000

Species Reactivity
Human

Products Data 

 

Western blot analysis of ACVR2B N-term S14 in Jurkat cell line lysates (35ug/lane).ACVR2B (arrow) was detected using the purified Pab.
Western blot analysis of anti-ACVR2B Antibody (N-term) in mouse heart, kidney and brain lysates (35ug/lane). ACVR2B (arrow) was detected using the purified Pab.

Specificity
This ACVR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2B.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Alternative Names
ACVR2B antibody, ACTRIIB antibody, ActR-IIB antibody, MGC116908 antibody, Activin receptor type-2B antibody, Activin receptor type IIB antibody

Description References
Harrison, C.A., et al., J. Biol. Chem. 279(27):28036-28044 (2004).
Martins da Silva, S.J., et al., Dev. Biol. 266(2):334-345 (2004).
Casagrandi, D., et al., Mol. Hum. Reprod. 9(4):199-203 (2003).
Shin, B.K., et al., J. Biol. Chem. 278(9):7607-7616 (2003).
Schneider-Kolsky, M.E., et al., Placenta 23(4):294-302 (2002). 

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途