ADSLAntibody(Center)
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
Epitomics | 暂无 | 暂无 | 现货 |
ADSL Antibody(Center)
Cat.#: T3470
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P30566
Mol Weight: 55kDa
Size: 100ug
Description
Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy.
Recommended Applications
WB, IHC, ELISA
Applications and Recommended Dilution Factors
WB: 1:100~500
IHC: 1:50~100
ELISA: 1:1,000
Species Reactivity
Human
Products Data
Western blot analysis of ADSL Antibody (Center) in NCI-H460, Hela, Jurkat cell line lysates (35ug/lane). ADSL (arrow) was detected using the purified Pab.
Formalin-fixed and paraffin-embedded human brain tissue reacted with ADSL Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Specificity
This ADSL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174~203 amino acids from the Center region of human ADSL.
Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Names
ADSL antibody, AMPS antibody, ASASE antibody, ASL antibody, Adenylosuccinate lyase antibody, Adenylosuccinase antibody
Description References
Stone,R.L., et.al., J. Biol. Chem. 268 (26), 19710-19716 (1993)
Mouchegh,K., et.al., J. Pediatr. 150 (1), 57-61 (2007)
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途