ALDH18A1 Antibody(Center)
Cat.#: T3580
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P54886
Mol Weight: 87kDa
Size: 100ug

Description
ALDH18A1 is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine.

Recommended Applications
WB, IHC, ELISA

Applications and Recommended Dilution Factors
WB: 1:100~500
IHC: 1:50~100
ELISA: 1:1,000

Species Reactivity
Human

Products Data  

 

Western blot analysis of ALDH18A1 Antibody (Center) in K562 cell line lysates (35ug/lane). ALDH18A1 (arrow) was detected using the purified Pab.
Formalin-fixed and paraffin-embedded human brain tissue reacted with ALDH18A1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
ALDH18A1 Antibody (Center) flow cytometric analysis of k562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specificity
This ALDH18A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183~213 amino acids from the Center region of human ALDH18A1.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Alternative Names
ALDH18A1 antibody, GSAS antibody, MGC117316 antibody, P5CS antibody, PYCS antibody, Gamma-glutamyl phosphate reductase antibody, Glutamate-5-semialdehyde dehydrogenase antibody, Glutamyl-gamma-semialdehyde dehydrogenase antibody

Description References
Hu,C.A., et.al., Amino Acids 35 (4), 665-672 (2008)
Bicknell,L.S., et.al., Eur. J. Hum. Genet. 16 (10), 1176-1186 (2008)

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途