ALDH4A1 Antibody(Center)
Cat.#: T2825
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P30038
Mol Weight: 62kDa
Size: 100ug

Description
ALDH4A1 belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline.

Recommended Applications
WB, IHC, ELISA

Applications and Recommended Dilution Factors
WB: 1:50~100
IHC: 1:50~100
ELISA: 1:1,000

Species Reactivity
Human

Products Data 

 

Western blot analysis of anti-ALDH4A1 Antibody (Center) in HepG2 cell line lysates (35ug/lane). ALDH4A1(arrow) was detected using the purified Pab.
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ALDH4A1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specificity
This ALDH4A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294~324 amino acids from the Center region of human ALDH4A1.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Alternative Names
ALDH4A1 antibody, ALDH4 antibody, DKFZp779M035 antibody, P5CD antibody, P5CDh antibody, Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial antibody, Aldehyde dehydrogenase family 4 member A1 antibody

Description References
Yoon,K.A., J. Hum. Genet. 49 (3), 134-140 (2004)
Geraghty,M.T., Hum. Mol. Genet. 7 (9), 1411-1415 (1998) 

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途