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Minisite
血管生成
GNF-2
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
G126166-25mg | 778270-11-4 | 询价 |
G126166-50mg | 778270-11-4 | 询价 |
G126166-250mg | 778270-11-4 | 询价 |
G126166-5mg | 778270-11-4 | 询价 |
产品介绍
- 分子式 C18H13F3N4O2
- 分子量374.32
- Beilstein号
- EC号
- MDL号 MFCD09265253
- PubChem编号 24724498
属性
溶解性 | Soluble in DMSO or EtOH |
存贮条件 | 储存温度 2-8°C |
描述
应用 | An inhibitor of c-Abl and Bcr-abl activity |
产品介绍 | GNF-2是一种高选择性,非ATP竞争性的Bcr-Abl抑制剂,对Flt3-ITD, Tel-PDGFR, TPR-MET和Tel-JAK1转化的肿瘤细胞没有作用活性。 |
备注 | GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, shows no activity to Flt3-ITD, Tel-PDGFR, TPR-MET and Tel-JAK1 transformed tumor cells. |
生化机理 | Bcr-abl Inhibitor is a cell-permeable pyrimidine compound that binds to and inhibits the c-Abl myristoyl binding pocket. Bcr-abl Inhibitor acts as an allosteric, non-ATP-competitive inhibitor of cellular Bcr-abl activity and Bcr-abl-dependent cellular functions. Bcr-abl Inhibitor exhibits little inhibitory effect against a panel of 63 kinases even at concentration as high as 10 μM, nor does it inhibit c-Abl or Bcr-abl in cell-free in vitro kinase assays. Bcr-abl inhibitor exhibits potent and selective antiproliferative activity toward Bcr-abl-expressing cells (IC50 = 138 nM, 194 nM, 268 nM and 273 nM in Ba/F3.p210, Ba/F3.p185Y253H, SUP-B15 and Ba/F3.p210E255V, and K562, respectively). |
别名 | GNF 2; 3-[6-[[4-(三氟甲氧基)苯基]氨基]-4-嘧啶基]苯甲酰胺;GNF 2;GNF2;Bcr-abl Inhibitor;3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide |
GNF-2信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于GNF-2报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途