诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
血管生成
PP2
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| P125361-5mg | 172889-27-9 | 询价 |
| P125361-100mg | 172889-27-9 | 询价 |
| P125361-25mg | 172889-27-9 | 询价 |
产品介绍
- 分子式 C15H16ClN5
- 分子量301.77
属性
| 沸点 | 493.54° C at 760 mmHg |
| 熔点 | 193.32°C |
| 折光率 | 1.68 |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.3600 |
描述
| 应用 | An effective and selective inhibitor of Src family kinases |
| 产品介绍 | PP2(AGL 1879) 是可逆的ATP竞争性的Src家族抑制剂，对p56lck，p59fynT，Hck和Src的IC50分别为4，5，5和100 nM。 |
| 生化机理 | PP 2 is an effective and selective inhibitor of c-Src family kinases. The inhibitor has been shown to inhibit Lck, FynT, phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). Additionally, PP 2 was reported to inhibit tyrosone kinase-dependent TcR-induced T cell proliferation. PP 2 studies indicate that this agent has demonstrated the ability to activate ERK 1, ERK 2 and p38. Research suggests that PP 2 may be useful to help identify c-Src family member substrates. MCF-7 cell research shows that PP 2 down regulates the expression of both enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 (PRDX3), and induces apoptosis. PP 2 is an inhibitor of casein kinase I δ and RICK. |
| 别名 | AGL 1879;PP 2;PP-2; 3-(4-氯苯基)-1-叔丁基-1H-吡唑并[3,4-d]嘧啶-4-胺;AGL 1879;PP 2;PP-2; PP 2 (enzyme inhibitor); Src kinase inhibitor PP2; 3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
PP2信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于PP2报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途