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血管生成
2-Methoxyestradiol (2-MeOE2)
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
AI问答
配套的仪器设备？
可以搭配的相关耗材试剂？
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| M125960-100mg | 362-07-2 | 询底价 |
| M125960-50mg | 362-07-2 | 询底价 |
| M125960-10mg | 362-07-2 | 询底价 |
| M125960-25mg | 362-07-2 | 询底价 |
| M125960-500mg | 362-07-2 | 询底价 |
产品介绍
- 分子式 C19H26O3
- 分子量302.41
- MDL号 MFCD00010489
- PubChem编号 24278561
属性
| 溶解性 | Soluble in DMSO (10 mg/mL), ethanol (10 mg/mL), chloroform, ethanol (1 mg/ml), and 1:1DMF:PBS(pH7.2) (0.5 mg/ml). Insoluble in water. |
描述
| 应用 | A disruptor of microtubule function and HIF-1 inhibitor |
| 产品介绍 | 2-Methoxyestradiol (2-MeOE2)使微管解聚，且抑制HIF-1α核积累和HIF转录活性。Phase 2。 |
| 备注 | 2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2. |
| 生化机理 | 2-methoxyestradiol (2ME2) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.2-Methoxyestradiol is an endogenous estrogen metabolite with low affinity for the estrogen receptor but which disrupts microtubule function. 2-Methoxyestradiol is formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. 2-Methoxyestradiol is a derivative of an oestrogenic steroidal hormone and has demonstrated: potent inhibition of endothelial cell proliferation and migration and inhibition of bFGF and VEGF-induced corneal neovascularization in mice. In MDA-MB-231 cells, 2-Methoxyestradiol inhibits HIF mediated transcriptional activation of target genes without affecting the transcription of HIF-1α itself. 2-Methoxyestradiol has been shown to induce apoptosis through activation of the p53 pathway through either activation of p38 and NF-κ |
| 别名 | 2-MeOE2;2-甲氧基-β-雌二醇;2-甲氧基雌二醇;2-ME2;(8R,9S,13S,14S,17S)-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol;2-Methoxy-β-estradiol |
2-Methoxyestradiol (2-MeOE2)信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于2-Methoxyestradiol (2-MeOE2)报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途