诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
细胞凋亡
Tenovin-1
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| T125146-50mg | 380315-80-0 | 询价 |
| T125146-25mg | 380315-80-0 | 询价 |
| T125146-10mg | 380315-80-0 | 询价 |
| T125146-100mg | 380315-80-0 | 询价 |
产品介绍
- 分子式 C20H23N3O2S
- 分子量369.48
属性
| 溶解性 | Soluble in DMSO (0.25 mg/ml), and DMF (0.25 mg/ml). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | An inhibitor of SIRT1 and SIRT2. |
| 产品介绍 | Tenovin-1防止MDM2介导的p53的降解，涉及泛素化途径，通过抑制SirT1和SirT2的蛋白脱乙酰活性。 |
| 备注 | Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. |
| 生化机理 | Tenovin-1 is a compound that belongs to the class of Tenovins, and inhibits SIRT1 and SIRT2. SIRT1 and SIRT2 are protein-deacetylases and are members of the NAD+-dependent class III histone deacetylases. Tenovin-1 has been shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro, and acetylate histone H4. Studies report that the water solubility of Tenovin-1 was increased by attaching a solubilizing group to the R2 position, creating a new Tenovin, Tenovin-6. Tenovin-1 is an activator of p21 and p53. |
| 别名 | N-[[[4-(乙酰氨基)苯基]氨基]硫代甲酰]-4-叔丁基苯甲酰胺;Tenovin 1;Tenovin 1;N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide |
Tenovin-1信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Tenovin-1报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途