非会员
诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
细胞凋亡
SU5416
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| S125835-50mg | 204005-46-9 | 询底价 |
| S125835-10mg | 204005-46-9 | 询底价 |
产品介绍
- 分子式 C15H14N2O
- 分子量238.28
- MDL号 MFCD01940922
- PubChem编号 24278606
属性
| 熔点 | 221-222 °C |
| 溶解性 | Soluble in DMSO (5 mg/ml), and ethanol (100 mM). Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | It was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain，and study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension. |
| 产品介绍 | Semaxanib (SU5416)是VEGFR(Flk-1/KDR)抑制剂，IC50为1.23 μM，比对PDGFRβ的抑制性高20倍，对EGFR，InsR和FGFR无活性。 |
| 生化机理 | VEGFR2 Kinase Inhibitor III is a cell-permeable ATP-competitive inhibitor of Flk-1 (VEGFR2/KDR, kinase insert domain receptor), which is the major growth factor for vascular endothelial cells. This receptor is a type III tyrosine kinase receptor that functions as the main mediator of VEGF-induced endothelial proliferation, survival, and migration. Studies suggest that VEGFR2 Kinase Inhibitor III also inhibits a variety of other receptors such as Met, Flt-3/Flk-2 (FLT-3 receptor tyrosine kinases), Ret, c-Kit, PDGFR, c-Abl and Arg (ABL), and ALK. In addition, VEGFR2 kinase inhibitor III regulates the signaling pathways used by oncogenic RET-transfected cells by regulating the extracellular signal regulated kinase (ERK) and JNK pathways. |
| 别名 | SU-5416; 1,3-二氢-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-2H-吲哚-2-酮;Semaxinib;SU-5416;VEGFR2 Kinase Inhibitor III; 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one |
SU5416信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于SU5416报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途