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Pifithrin-α (PFTα)
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| P129961-10mg | 63208-82-2 | 询价 |
| P129961-50mg | 63208-82-2 | 询价 |
产品介绍
- 分子式 C16H18N2OS·HBr
- 分子量367.30
- Beilstein号
- EC号
- MDL号 MFCD00417851
- PubChem编号 24898529
属性
| 敏感性 | 对光和热敏感 |
| 溶解性 | Soluble in DMSO (20 mg/ml), water, DMF (~1 mg/ml), 1:10 DMSO:PBS (pH 7.2) (~ 0.1 mg/ml), 100% ethanol, and methanol. Sparingly soluble in aqueous buffers. |
| 存贮条件 | 储存温度 -20°C，避光保存 |
描述
| 应用 | An inhibitor of p53 that reversibly blocks p53 dependent transcriptional activation and apoptosis. |
| 产品介绍 | Pifithrin-α (PFTα)是一种p53抑制剂，抑制p53依赖性的p53应答基因转录。 |
| 备注 | Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. |
| 生化机理 | Pifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. It enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic compounds including doxorubicin , etopoxide, paclitaxel, and cytosine-β-D-arabinofuranoside. Pifithrin-α protects mice from lethal whole body γ-irradiation, and does not induce visible tumors. Protects against neuronal death in models of stroke and neurodegenerative disorders. Pifithrin-α is also an aryl hydrocarbon receptor (AHR) agonist, which leads to the upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM). |
| 别名 | 皮斐松;Pifithrin-α hydrobromide;Pifithrin hydrobromide; Pifithrin-(alpha) hydrobromide; PFT(alpha) hydrobromide;1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide |
Pifithrin-α (PFTα)信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Pifithrin-α (PFTα)报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途