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Pemetrexed
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
货号 | CAS号 | 操作 |
---|---|---|
P125303-1g | 137281-23-3 | 询价 |
P125303-250mg | 137281-23-3 | 询价 |
P129841-50mg | 150399-23-8 | 询价 |
P129841-250mg | 150399-23-8 | 询价 |
- 分子式 C20H21N5O6
- 分子量427.41
属性
溶解性 | 25°C: DMSO 1mg/mL Water 94 mg/mL Ethanol <1 mg/mL |
存贮条件 | 储存温度-20°C |
描述
产品介绍 | Pemetrexed是抗叶酸和抗代谢剂,对TS,DHFR和GARFT的Ki分别为1.3 nM,7.2 nM和65 nM。 |
生化机理 |
Description: IC50 Value: 1.3nM(Ki for TS); 7.2nM(DHFR); 65nM(GARFT) Pemetrexed is approved as a first-line treatment for advanced non-squamous non-small cell lung cancer (NSCLC) with cisplatin and as a single agent for second-line treatment or for patients who show no disease progression after four cycles of platinum-based doublet induction chemotherapy as maintenance therapy. in vitro: The Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibition against TS, DHFR, and GARFT, respectively. In contrast, although a similar high level of inhibitory potency was observed for the parent monoglutamate against DHFR (7.0 nM), the inhibition constants (Ki) for the parent monoglutamate are significantly weaker for TS (109 nM) and GARFT(9,300 nM).The parent monoglutamate LY231514 inhibited rhTS with a Ki of 109 nM when the monoglutamated form of the substrate (6R-MTHF) (6[R]-5,l0-meth ylenetetrahydrofolate) was used. This is in good agreement with the Ki v |
别名 | LY231514;Alimta;LY 231514;LY-231514;培美曲塞酸;LY231514;Alimta;LY 231514;LY-231514 |
Pemetrexed信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于Pemetrexed报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途