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Minisite
细胞凋亡
Apoptosis Activator 2
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
A129309-10mg | 79183-19-0 | 询价 |
A129309-50mg | 79183-19-0 | 询价 |
产品介绍
- 分子式 C15H9Cl2NO2
- 分子量306.14
属性
敏感性 | 对光敏感 |
溶解性 | Soluble in DMSO (5 mg/ml), methanol (5 mg/ml), and ethanol.; DMSO 61 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
存贮条件 | 储存温度 2-8°C |
描述
应用 | An indoledione caspase activator |
产品介绍 |
Apoptosis Activator 2强诱导caspase-3激活, PARP分裂, DNA断裂,导致细胞破坏(Apaf-1依赖性的),IC50约为4 μM,抑制HMEC, PREC和MCF-10A细胞活性。 |
备注 | Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. |
生化机理 | Apoptosis Activator 2 is a cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 μM for Jurkat, Molt-4, and CCRF-CEM). Apoptosis Activator 2 shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1. Apoptosis Activator 2 is an activator of caspase-3. |
别名 | 1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮;凋亡活化剂 2;1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione |
Apoptosis Activator 2信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于Apoptosis Activator 2报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途