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HMN-214
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| H125770-5mg | 173529-46-9 | 询价 |
| H125770-100mg | 173529-46-9 | 询价 |
| H125770-25mg | 173529-46-9 | 询价 |
产品介绍
- 分子式 C22H20N2O5S
- 分子量424.48
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A potent inhibitor of Polo-like kinase and a broad-spectrum anti-tumor agent |
| 产品介绍 | HMN-214(IVX214)是PLK1抑制剂，平均IC50为0.12 μM。 |
| 生化机理 | HMN-214 (IVX-214) is a potent inhibitor of Polo-like kinase (Plk) with IC50 of 118 nM. HMN-214 shows potent and broad-spectrum anti-tumor activity against various cancer cells, including HeLa, PC-3, DU-145, MIAPaCa-2, U937, MCF-7, A549, and WiDr, with a mean IC50 value of 118 nM. HMN-176 is also cytotoxic to drug-resistant human and murine cell lines, including P388/CDDP, P388/VCR, K2/CDDP, and K2/VP-16, with IC50 values ranging from 143 nM–265 nM. In HeLa cells, HMN-176 (3 μM) blocks cell cycle at G2/M phase. HMN-176 (3 μM) down-regulates the expression of the multi-drug resistance gene (MDR1), due to the disturbance of NF-Y transcription factor binding to the MDR1 promoter. HMN-176 (250 nM–2.5 μM) inhibits meiotic spindle assembly and aster formation of Spisula oocytes. HMN-176 (2.5 μM) also inhibits aster microtubule formation from human centrosomes. |
| 别名 | HMN214;HMN 214; (E)-4-(2-(2-(N-乙酰基-N-((4-甲氧基苯基)磺酰)氨基)苯基)乙烯基)吡啶 1-氧化物;;IVX-214;IVX 214;IVX-214;IVX214;(e)-4-(2-(2-(n-acetyl-n-((4-methoxyphenyl)sulfonyl)amino)phenyl)ethenyl)pyridine 1-oxide |
HMN-214信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于HMN-214报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途