Description:
IC50 Value: 0.4nM [1]
GSK2606414 is an orally available, potent, and selective PERK inhibitor. Compound 38 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states [1]. It is implicated that PERK plays an important role in tumorigenesis and cancer cell survival.
in vitro: N/A
in vivo: N/A
Clinical trial: N/A