诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
细胞凋亡
Flavopiridol
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| F124946-25mg | 146426-40-6 | 询价 |
| F124946-5mg | 146426-40-6 | 询价 |
| F124946-100mg | 146426-40-6 | 询价 |
产品介绍
属性
| 溶解性 | DMSO ≥14mg/mL Water <1.2mg/mL Ethanol ≥7.8mg/mL;Soluble in chloroform, and water (slightly soluble). |
| 存贮条件 | 储存温度2-8°C |
描述
| 应用 | A synthetic flavonoid derivative, potent inhibitor of CDKs. |
| 产品介绍 | Flavopiridol能与ATP竞争抑制CDK，对CDK1，CDK2，CDK4和CDK6的IC50为40 nM，同时对EGFR和PKA也有一定抑制性。 |
| 生化机理 | Flavopiridol is a synthetic flavone compound that inhibits the phosphorylation of cyclin-dependent kinases (Cdks) and suppresses expression of cyclin D1 and D3, interrupting the central role of Cdks in the regulation of the cell cycle and consequently promoting apoptosis. This action has been exploited in studies investigating the suppression of oncogenic proliferation, synovial hyperplasia, and joint destruction related to rheumatoid arthritis. Flavopiridol is an inhibitor of Cdk1, Cdk10, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8 and Cdk9. |
| 别名 | L868275; HMR-1275;夫拉平度; 2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]苯并吡喃-4-酮;L868275; HMR-1275; Alvocidib;2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one |
Flavopiridol信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Flavopiridol报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途