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Palbociclib isethionate
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| E129978-100mg | 827022-33-3 | 询价 |
| E129978-25mg | 827022-33-3 | 询价 |
| E129978-500mg | 827022-33-3 | 询价 |
产品介绍
- 分子式 C24H29N7O2·C2H6O4S
- 分子量573.66
- Beilstein号
- EC号
- MDL号 MFCD22666589
- PubChem编号
属性
| 溶解性 | DMSO <1 mg/mL (<1 mM); Water 50 mg/mL heating (87.15 mM); Ethanol <1 mg/mL (<1 mM) |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 |
PD 0332991 isethionate has been used: · to incubate MCF10A cells to verify cyclin D1 inhibition of autophagy involved cyclin-dependent kinase activity · as a cyclin dependent kinase 4 (CDK4) inhibitor to study its anticonvulsive property in Drosophila · to mimic the inhibitory effect of 5α-dihydrotestosterone (DHT) on HPr-1AR cell cycle progression and growth |
| 产品介绍 | Palbociclib (PD0332991) Isethionate是一种高度选择性的CDK4/6抑制剂，IC50为11 nM/16 nM，对CDK1/2/5， EGFR， FGFR， PDGFR， InsR等没有抑制活性。Phase 3。 |
| 合法信息 | Sold for only research purposes |
| 备注 | Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 2/3. |
| 生化机理 | PD 0332991 is a potent selective inhibitor of cyclin dependent kinases CDK4 and CDK6 with in vitro IC50 = 11 nM (CDK4) and 16 nM (CDK6). PD 0332991 induces G1 arrest in retinoblastoma (Rb)-positive tumor cells. PD 0332991 might act as a chemsensitizer. It is useful in the treatment of breast cancer along with antioestrogens. PD 0332991 is also known to possess antitumor action. |
| 别名 | 6-乙酰基-8-环戊基-5-甲基-2 - [[5-（1-哌嗪基）-2-吡啶基]氨基]吡啶并[2,3-d]嘧啶-7（8H） - 酮2-羟基 - 乙磺酸（1：1）, 帕博西尼羟乙基磺酸盐;PD0332991 isethionate; PD-0332991 isethionate; PD 0332991 isethionate;6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxy-ethanesulfonic acid (1:1) |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途