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EI1
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| E125706-25mg | 1418308-27-6 | 询价 |
| E125706-5mg | 1418308-27-6 | 询价 |
| E125706-100mg | 1418308-27-6 | 询价 |
产品介绍
- 分子式 C23H26N4O2
- 分子量390.48
属性
| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | EI1是EZH2选择性抑制剂，对野生型EZH2和EZH2 Y641F突变型的IC50分别为15 nM和13 nM。 |
| 生化机理 | EI1 demonstrated potent, concentration-dependent inhibition of the enzymatic activity against both Ezh2 wild-type and Y641F mutant enzymes with IC50 of 15 ± 2 nM and 13 ± 3 nM, respectively. Although SAM is the common cofactor for all HMTs, EI1 showed remarkable selectivity against Ezh2 over other HMTs. EI1 dramatically inhibited the H3K27me3 and H3K27me2 levels in these cells in a dose-dependent manner, but H3K27me1 was largely unchanged. The effect was similar in these cell lines, although they have different basal H3K27me3 and H3K27me2 levels. For example, in WSU-DLCL2, SU-DHL6, and Karpas422 with Ezh2 mutations, the H3K27me3 level was much higher than that in DLBCL cells with wild-type Ezh2 |
| 别名 | EI-1;EI 1;6-氰基-N-[(1,2-二氢-4,6-二甲基-2-氧代-3-吡啶基)甲基]-1-(1-乙基丙基)-1H-吲哚-4-甲酰胺;Ezh2 inhibitor；6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide |
EI1信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于EI1报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途