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细胞凋亡
CHIR-124
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
C125171-100mg | 405168-58-3 | 询价 |
C125171-1mg | 405168-58-3 | 询价 |
C125171-25mg | 405168-58-3 | 询价 |
C125171-2mg | 405168-58-3 | 询价 |
C125171-5mg | 405168-58-3 | 询价 |
产品介绍
- 分子式 C23H22ClN5O
- 分子量419.91
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
备注 | CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2. |
生化机理 |
CHIR-124 is a novel and potent chk1 inhibitor with an IC50 of 0.3 nM. Chk1 kinase is a critical regulator of both the S and G2/M phase cell cycle checkpoints in response to DNA damage. CHIR-124 has been shown that inhibitors of chk1 can selectively sensitize tumor cells with mutant p53 to genotoxic agents. |
别名 | (S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one;(S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one |
CHIR-124信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于CHIR-124报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途