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Minisite
细胞凋亡
BI 2536
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
B129994-5mg | 755038-02-9 | 询价 |
B129994-10mg | 755038-02-9 | 询价 |
B129994-100mg | 755038-02-9 | 询价 |
B129994-50mg | 755038-02-9 | 询价 |
产品介绍
- 分子式 C28H39N7O3
- 分子量521.66
属性
溶解性 | DMSO 21 mg/mL Water <1 mg/mL Ethanol 100 mg/mL |
存贮条件 | 储存温度-20°C |
描述
应用 | A Plk inhibitor with efficacy against 32 cancer cell lines. |
产品介绍 | BI 2536是一种有效的Plk1抑制剂,IC50为0.83 nM,比作用于Plk2和Plk3选择性分别高4和11倍。 |
备注 | BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2. |
生化机理 | BI 2536 treatment ranging from 10 nM to 100 nM blocks the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibits of cohesin release from chromosome arms, and induces monopolar spindle formation and other Plk1 dependent processes. BI 2536 treatment leads to the HeLa cells arrested in the G2/M stage. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM. |
别名 | 4-[[(7R)-8-环戊基-7-乙基-5,6,7,8-四氢-5-甲基-6-氧代-2-喋啶基]氨基]-3-甲氧基-N-(1-甲基-4-哌啶基)苯甲酰胺;BI-2536; BI2536;BI-2536; BI2536;4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide; Boehringer PLK-1 inhibitor |
BI 2536信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于BI 2536报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途