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BIX-01294
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
货号 | CAS号 | 操作 |
---|---|---|
B127141-5mg | 935693-62-2 | 询价 |
B127141-100mg | 935693-62-2 | 询价 |
B127141-25mg | 935693-62-2 | 询价 |
- 分子式 C28H38N6O2
- 分子量490.64
属性
熔点 | 178.44° C |
折光率 | 1.54 |
溶解性 | DMSO |
存贮条件 | 储存温度-20°C |
密度 | 1.6000 |
描述
应用 | A selective large conductance calcium activated potassium channel activator |
产品介绍 | BIX01294是G9a组蛋白甲基转移酶(HMTase)抑制剂,IC50为2.7 μM。 |
生化机理 |
BIX-01294, a diazepin-quinazolinamine derivative, is a selective inhibitor of G9a histone methyl transferase (G9a HMTase) that impairs G9a HMTase and generation of H3K9me2 in vitro. In its inhibition of the histone lysine methyltransferases, BIX-01294 does not compete with cofactor S-adenosyl-methionine. G9a HMTase regulates gene expression including one of the pluripotency genes Oct4. It is reported that BIX-01294 enhances reprogramming efficiency of neural progenitor cells to the same levels as when four transcription factors (Oct4, Klf4, Sox2 and c-Myc) were introduced to somatic cells for generation of induced pluripotent stem cells. BIX-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes. |
别名 | BIX 01294; BIX01294;2-(六氢-4-甲基-1H-1,4-二氮杂卓-1-基)-6,7-二甲氧基-N-(1-(苯基甲基)-4-哌啶基)-4-喹唑啉胺;;BIX 01294; BIX01294; 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-(1-(phenylmethyl)-4-piperidinyl)-4-quinazolinamine;1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one |
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途